Cortical changes in the parkinsonian brain: a contribution to the delineation of “diffuse Lewy body disease”
Identifieur interne : 000F92 ( Main/Corpus ); précédent : 000F91; suivant : 000F93Cortical changes in the parkinsonian brain: a contribution to the delineation of “diffuse Lewy body disease”
Auteurs : M. YoshimuraSource :
- Journal of Neurology [ 0340-5354 ] ; 1983-03-01.
Abstract
Summary: A group of 55 autopsy cases of paralysis agitans were studied with special attention to distribution of Lewy bodies and cortical changes. According to the frequency of Lewy bodies and senile changes (senile plaques and Alzheimer neurofibrillary tangles), three groups could be distinguished. Group A (4 cases; 3 males, 1 female; aged 65–76 years) with progressive dementia and muscle rigidity showed numerous Lewy bodies, not only in the diencephalon and brain-stem but also in the cerebral cortex, and a high incidence of senile changes. The pattern of distribution of Lewy bodies in the brain-stem was identical to that of Parkinson's disease. Cerebral Lewy bodies were observed predominantly in small or medium-sized pyramidal neurons in the fifth and sixth layers of the temporal, frontal, insular and cingulate cortex. These cases are termed “diffuse Lewy body disease”. Group B (15 cases; 10 males, 5 females; aged 62–79 years) with classical parkinsonism showed many Lewy bodies in the diencephalon and brain-stem, but cerebral Lewy bodies and senile changes were less frequent than in group A. In group B, the frequency of cerebral Lewy bodies and senile changes was higher in patients with dementia (7 cases, 40%) than in patients without dementia. The demented patients in this group may form a transition between groups B and A. Group C (36 cases; 17 males, 19 females; aged 52–85 years) without dementia, showed fewer Lewy bodies in the diencephalon and brain-stem than in groups A and B; cerebral Lewy bodies were not found. The frequency of senile changes corresponded to age. Clinicopathologically, the cases in groups B and C correspond to classical paralysis agitans.
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DOI: 10.1007/BF00313493
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According to the frequency of Lewy bodies and senile changes (senile plaques and Alzheimer neurofibrillary tangles), three groups could be distinguished. Group A (4 cases; 3 males, 1 female; aged 65–76 years) with progressive dementia and muscle rigidity showed numerous Lewy bodies, not only in the diencephalon and brain-stem but also in the cerebral cortex, and a high incidence of senile changes. The pattern of distribution of Lewy bodies in the brain-stem was identical to that of Parkinson's disease. Cerebral Lewy bodies were observed predominantly in small or medium-sized pyramidal neurons in the fifth and sixth layers of the temporal, frontal, insular and cingulate cortex. These cases are termed “diffuse Lewy body disease”. Group B (15 cases; 10 males, 5 females; aged 62–79 years) with classical parkinsonism showed many Lewy bodies in the diencephalon and brain-stem, but cerebral Lewy bodies and senile changes were less frequent than in group A. In group B, the frequency of cerebral Lewy bodies and senile changes was higher in patients with dementia (7 cases, 40%) than in patients without dementia. The demented patients in this group may form a transition between groups B and A. Group C (36 cases; 17 males, 19 females; aged 52–85 years) without dementia, showed fewer Lewy bodies in the diencephalon and brain-stem than in groups A and B; cerebral Lewy bodies were not found. The frequency of senile changes corresponded to age. Clinicopathologically, the cases in groups B and C correspond to classical paralysis agitans.</p></abstract><abstract xml:lang="de"><p>Zusammenfassung: 55 Fälle mit histopathologischer Diagnose „Paralysis agitans (PA)” wurden neuropathologisch untersucht; nach Häufigkeit und Verteilung der Lewy-Körperchen sowie seniler Veränderungen wurde 3 Gruppen unterschieden. Gruppe A: 4 Fälle von hochgradiger, progressiver Demenz mit Muskelrigor zeigen neben ausgeprägten senilen Veränderungen zahlreich Lewy-Körperchen in corticalen Nervenzellen. Die Verteilung der Lewy-Körperchen in Zwischenhirn und Hirnstamm entsprach der klassischen PA. Diese Fälle bezeichnen wir als „diffuse Lewy-Körperchen-Krankheit“. Gruppe B: 15 Fälle mit Parkinson-Syndrom und leichter bis mäßiger Demenz (in 40% der Fälle) zeigten nur einzelne corticale Lewy-Körperchen bei zahlreicheren Lewy-Körperchen in Zwischenhirn und Hirnstamm und geringeren senilen Veränderungen als bei Gruppe A. Die Fälle mit Demenz bei Gruppe B könnten als Übergangsfälle zur Gruppe A angesehen werden. Gruppe C: 36 Fälle mit Parkinson-Syndrom ohne Demenz zeigten das Vorkommen von Lewy-Körperchen mit etwas geringerer Häufigkeit als bei Gruppe A und B im Zwischenhirn und Hirnstamm, jedoch nicht in der Hirnrinde. Im klinisch-pathologischen Aspekt entsprachen die Gruppen B und C der klassischen PA.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Neurosciences</term></item><item><term>Neuroradiology</term></item><item><term>Neurology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1982-05-11">Created</change><change when="1983-03-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-2">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/887EAEC7FA7C1DAA1A892A218872245EC26F6A21/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>415</JournalID><JournalPrintISSN>0340-5354</JournalPrintISSN><JournalElectronicISSN>1432-1459</JournalElectronicISSN><JournalTitle>Journal of Neurology</JournalTitle><JournalAbbreviatedTitle>J Neurol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Neurosciences</JournalSubject><JournalSubject Type="Secondary">Neuroradiology</JournalSubject><JournalSubject Type="Secondary">Neurology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>229</VolumeIDStart><VolumeIDEnd>229</VolumeIDEnd><VolumeIssueCount>4</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>9</IssueArticleCount><IssueHistory><CoverDate><Year>1983</Year><Month>3</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1983</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art3"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00313493</ArticleID><ArticleDOI>10.1007/BF00313493</ArticleDOI><ArticleSequenceNumber>3</ArticleSequenceNumber><ArticleTitle Language="En">Cortical changes in the parkinsonian brain: a contribution to the delineation of “diffuse Lewy body disease”</ArticleTitle><ArticleCategory>Original Investigations</ArticleCategory><ArticleFirstPage>17</ArticleFirstPage><ArticleLastPage>32</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>8</Month><Day>25</Day></RegistrationDate><Received><Year>1982</Year><Month>5</Month><Day>11</Day></Received></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1983</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>415</JournalID><VolumeIDStart>229</VolumeIDStart><VolumeIDEnd>229</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1 Aff2" CorrespondingAffiliationID="Aff2"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><FamilyName>Yoshimura</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgName>Neurological Institute of the University of Vienna</OrgName><OrgAddress><Country>Austria</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Pathology</OrgDivision><OrgName>Tokyo Metropolitan Geriatric Hospital</OrgName><OrgAddress><Street>35-2 Sakaecho, Itabashi-ku</Street><Postcode>173</Postcode><City>Tokyo</City><Country>Japan</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>A group of 55 autopsy cases of paralysis agitans were studied with special attention to distribution of Lewy bodies and cortical changes. According to the frequency of Lewy bodies and senile changes (senile plaques and Alzheimer neurofibrillary tangles), three groups could be distinguished.</Para><Para>Group A (4 cases; 3 males, 1 female; aged 65–76 years) with progressive dementia and muscle rigidity showed numerous Lewy bodies, not only in the diencephalon and brain-stem but also in the cerebral cortex, and a high incidence of senile changes. The pattern of distribution of Lewy bodies in the brain-stem was identical to that of Parkinson's disease. Cerebral Lewy bodies were observed predominantly in small or medium-sized pyramidal neurons in the fifth and sixth layers of the temporal, frontal, insular and cingulate cortex. These cases are termed “diffuse Lewy body disease”.</Para><Para>Group B (15 cases; 10 males, 5 females; aged 62–79 years) with classical parkinsonism showed many Lewy bodies in the diencephalon and brain-stem, but cerebral Lewy bodies and senile changes were less frequent than in group A. In group B, the frequency of cerebral Lewy bodies and senile changes was higher in patients with dementia (7 cases, 40%) than in patients without dementia. The demented patients in this group may form a transition between groups B and A.</Para><Para>Group C (36 cases; 17 males, 19 females; aged 52–85 years) without dementia, showed fewer Lewy bodies in the diencephalon and brain-stem than in groups A and B; cerebral Lewy bodies were not found. The frequency of senile changes corresponded to age. Clinicopathologically, the cases in groups B and C correspond to classical paralysis agitans.</Para></Abstract><Abstract ID="Abs2" Language="De"><Heading>Zusammenfassung</Heading><Para>55 Fälle mit histopathologischer Diagnose „Paralysis agitans (PA)” wurden neuropathologisch untersucht; nach Häufigkeit und Verteilung der Lewy-Körperchen sowie seniler Veränderungen wurde 3 Gruppen unterschieden. Gruppe A: 4 Fälle von hochgradiger, progressiver Demenz mit Muskelrigor zeigen neben ausgeprägten senilen Veränderungen zahlreich Lewy-Körperchen in corticalen Nervenzellen. Die Verteilung der Lewy-Körperchen in Zwischenhirn und Hirnstamm entsprach der klassischen PA. Diese Fälle bezeichnen wir als „diffuse Lewy-Körperchen-Krankheit“. Gruppe B: 15 Fälle mit Parkinson-Syndrom und leichter bis mäßiger Demenz (in 40% der Fälle) zeigten nur einzelne corticale Lewy-Körperchen bei zahlreicheren Lewy-Körperchen in Zwischenhirn und Hirnstamm und geringeren senilen Veränderungen als bei Gruppe A. Die Fälle mit Demenz bei Gruppe B könnten als Übergangsfälle zur Gruppe A angesehen werden. Gruppe C: 36 Fälle mit Parkinson-Syndrom ohne Demenz zeigten das Vorkommen von Lewy-Körperchen mit etwas geringerer Häufigkeit als bei Gruppe A und B im Zwischenhirn und Hirnstamm, jedoch nicht in der Hirnrinde. Im klinisch-pathologischen Aspekt entsprachen die Gruppen B und C der klassischen PA.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Diffuse Lewy body disease</Keyword><Keyword>Parkinsonism</Keyword><Keyword>Lewy bodies</Keyword><Keyword>Senile changes</Keyword></KeywordGroup><ArticleNote Type="PresentedAt"><SimplePara>A short preliminary version of the paper was presented at the Scientific Annual Meeting of the Austrian Society of Neuropathology with International Participation, Graz, May 7–8, 1981</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cortical changes in the parkinsonian brain: a contribution to the delineation of “diffuse Lewy body disease”</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cortical changes in the parkinsonian brain: a contribution to the delineation of “diffuse Lewy body disease”</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">M.</namePart><namePart type="family">Yoshimura</namePart><affiliation>Neurological Institute of the University of Vienna, Austria</affiliation><affiliation>Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, 173, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1982-05-11</dateCreated><dateIssued encoding="w3cdtf">1983-03-01</dateIssued><copyrightDate encoding="w3cdtf">1983</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: A group of 55 autopsy cases of paralysis agitans were studied with special attention to distribution of Lewy bodies and cortical changes. According to the frequency of Lewy bodies and senile changes (senile plaques and Alzheimer neurofibrillary tangles), three groups could be distinguished. Group A (4 cases; 3 males, 1 female; aged 65–76 years) with progressive dementia and muscle rigidity showed numerous Lewy bodies, not only in the diencephalon and brain-stem but also in the cerebral cortex, and a high incidence of senile changes. The pattern of distribution of Lewy bodies in the brain-stem was identical to that of Parkinson's disease. Cerebral Lewy bodies were observed predominantly in small or medium-sized pyramidal neurons in the fifth and sixth layers of the temporal, frontal, insular and cingulate cortex. These cases are termed “diffuse Lewy body disease”. Group B (15 cases; 10 males, 5 females; aged 62–79 years) with classical parkinsonism showed many Lewy bodies in the diencephalon and brain-stem, but cerebral Lewy bodies and senile changes were less frequent than in group A. In group B, the frequency of cerebral Lewy bodies and senile changes was higher in patients with dementia (7 cases, 40%) than in patients without dementia. The demented patients in this group may form a transition between groups B and A. Group C (36 cases; 17 males, 19 females; aged 52–85 years) without dementia, showed fewer Lewy bodies in the diencephalon and brain-stem than in groups A and B; cerebral Lewy bodies were not found. The frequency of senile changes corresponded to age. Clinicopathologically, the cases in groups B and C correspond to classical paralysis agitans.</abstract><abstract lang="de">Zusammenfassung: 55 Fälle mit histopathologischer Diagnose „Paralysis agitans (PA)” wurden neuropathologisch untersucht; nach Häufigkeit und Verteilung der Lewy-Körperchen sowie seniler Veränderungen wurde 3 Gruppen unterschieden. Gruppe A: 4 Fälle von hochgradiger, progressiver Demenz mit Muskelrigor zeigen neben ausgeprägten senilen Veränderungen zahlreich Lewy-Körperchen in corticalen Nervenzellen. Die Verteilung der Lewy-Körperchen in Zwischenhirn und Hirnstamm entsprach der klassischen PA. Diese Fälle bezeichnen wir als „diffuse Lewy-Körperchen-Krankheit“. Gruppe B: 15 Fälle mit Parkinson-Syndrom und leichter bis mäßiger Demenz (in 40% der Fälle) zeigten nur einzelne corticale Lewy-Körperchen bei zahlreicheren Lewy-Körperchen in Zwischenhirn und Hirnstamm und geringeren senilen Veränderungen als bei Gruppe A. Die Fälle mit Demenz bei Gruppe B könnten als Übergangsfälle zur Gruppe A angesehen werden. Gruppe C: 36 Fälle mit Parkinson-Syndrom ohne Demenz zeigten das Vorkommen von Lewy-Körperchen mit etwas geringerer Häufigkeit als bei Gruppe A und B im Zwischenhirn und Hirnstamm, jedoch nicht in der Hirnrinde. Im klinisch-pathologischen Aspekt entsprachen die Gruppen B und C der klassischen PA.</abstract><note>Original Investigations</note><note>A short preliminary version of the paper was presented at the Scientific Annual Meeting of the Austrian Society of Neuropathology with International Participation, Graz, May 7–8, 1981</note><relatedItem type="host"><titleInfo><title>Journal of Neurology</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol</title></titleInfo><genre type="Journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1983-03-01</dateIssued><copyrightDate encoding="w3cdtf">1983</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Neurosciences</topic><topic>Neuroradiology</topic><topic>Neurology</topic></subject><identifier type="ISSN">0340-5354</identifier><identifier type="eISSN">1432-1459</identifier><identifier type="JournalID">415</identifier><identifier type="IssueArticleCount">9</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1983</date><detail type="volume"><number>229</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>17</start><end>32</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1983</recordOrigin></recordInfo></relatedItem><identifier type="istex">887EAEC7FA7C1DAA1A892A218872245EC26F6A21</identifier><identifier type="DOI">10.1007/BF00313493</identifier><identifier type="ArticleID">Art3</identifier><identifier type="ArticleID">BF00313493</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1983</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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